What does it mean when you hear narrow therapeutic index in drug administration?
Therapeutic Index (TI) refers to a therapeutic ratio where the efficiency of medication is optimised. Dr Wang Aiwen, Senior Pharmacist, from the Department of Pharmacy at Singapore General Hospital shares 5 tips when taking TI medicine. Show
Therapeutic index (TI) is also commonly referred as a therapeutic window, safety window or therapeutic ratio. This is the dose range where the efficacy of medication is optimised while side-effects are minimised. The figure below visually demonstrates the concept.
5 TIPS WHEN TAKING THERAPEUTIC INDEX (TI) MEDICINEIf you are taking any of the therapeutic index (TI) medicines listed above, here are some tips to ensure your safety:
When in doubt about your medications, discuss your concerns with your doctor or pharmacist. Ref: O17
Under a Creative Commons license Open access AbstractAn appropriate therapeutic index is crucial for drug discovery and development since narrow therapeutic index (NTI) drugs with slight dosage variation may induce severe adverse drug reactions or potential treatment failure. To date, the shared characteristics underlying the targets of NTI drugs have been explored by several studies, which have been applied to identify potential drug targets. However, the association between the drug therapeutic index and the related disease has not been dissected, which is important for revealing the NTI drug mechanism and optimizing drug design. Therefore, in this study, two classes of disease (cancers and cardiovascular disorders) with the largest number of NTI drugs were selected, and the target property of the corresponding NTI drugs was analyzed. By calculating the biological system profiles and human protein–protein interaction (PPI) network properties of drug targets and adopting an AI-based algorithm, differentiated features between two diseases were discovered to reveal the distinct underlying mechanisms of NTI drugs in different diseases. Consequently, ten shared features and four unique features were identified for both diseases to distinguish NTI from NNTI drug targets. These computational discoveries, as well as the newly found features, suggest that in the clinical study of avoiding narrow therapeutic index in those diseases, the ability of target to be a hub and the efficiency of target signaling in the human PPI network should be considered, and it could thus provide novel guidance in the drug discovery and clinical research process and help to estimate the drug safety of cancer and cardiovascular disease. KeywordsNarrow therapeutic index Cancer Cardiovascular disease Artificial intelligence Drug mechanism Cited by (0)© 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. What does it mean to have a narrow therapeutic index?Introduction. Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What is narrow therapeutic index in pharmacology?Narrow therapeutic index (NTI) drugs are defined as those drugs where small differences in dose or blood concentration may lead to dose and blood concentration dependent, serious therapeutic failures or adverse drug reactions.
What will happen if the therapeutic index value is smaller?The larger the TI, the safer the drug is. Conversely, a drug with a narrow TI has generally a steep concentration–response relationship for efficacy, toxicity or both so that there is a narrowly defined range between risk and benefit.
What does it mean when a drug has a wide therapeutic index?A large (or high) therapeutic index number means there is a large therapeutic window between the effective concentration and the toxic concentration of a medication, so the drug is relatively safe.
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