Michael A. Gropper MD, PhD, in Miller's Anesthesia, 2020Respiratory Physiology and Pathophysiology
Spirometry—Total Lung Capacity and Subdivisions
The gas volume in the lung after a maximum inspiration is called thetotal lung capacity [TLC; usually 6 to 8 L]. TLC can be increased in COPD either by overexpansion of alveoli or by destruction of the alveolar wall, resulting in loss of elastic tissue, as in emphysema [seeFig. 13.4].78 In extreme cases, TLC can be increased to 10 to 12 L. In restrictive lung disease, TLC is reduced, reflecting the degree of fibrosis, and can be as low as 3 to 4 L [seeFig. 13.4].78
Following maximum expiratory effort, some air is left in the lung and constitutes the RV [approximately 2 L]. However, usually no region develops collapse because distal airways [